We studied the diuretic effect of furosemide according to the different methods of addministration of fuosemide, such as bolus injection(BOLUS0 and loading followed by continuous infusion(LOADING), with normal control9NC) in 26 rabbits by giving
epual
dose of furosemide.
Bolus injection of 0.0mg/kg furosemide was done to the BOLUS and the same total dose of furosemide also was given to the LOADING by a loading dose of 0.12mg/kg furosemide followed by continuous infuasion at a rate of 0.06mg/kg/hr for 8 hours.
Total urine volume(NG: 34.4±14.1mL/kg, BOLUS: 61.9±17.0ml/kg, LOADING: 93.3±15.9ml/kg) and sodium(NG: 4.8±2.0mEq/kg, BOLUS: 7.5±1.5mEq/kg, LOADING: 10.2±2.5m/eq/kg), chloride(NC: 3.3±1.3mEq/kg, BOLUS: 7.5±1.1mEq/kg, LOADING
11.0±1.6mEq/kg)
were
significantly greater in LOADING when compared with NG and BOLUS(p<0.05). Furosemide efficiency was higher in LOADING during study hours.
These data revealed that diuretic effect of furosemide was greater when furosemide was given by the method of loading injection followed by continuous infusion compared with bolus injection despite same dosage was given to the rabbits possibly
resulting
from furosemide efficiency being more consistently higher in loading group during the experiment period.
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